3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol

Base Information

• Chemical Name: 3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol
• CAS No.: 157617-60-2
• Molecular Formula: C₂₉H₃₀OP₂
• Molecular Weight: 456.504
• Mol file: 157617-60-2.mol

Synonyms:3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol

Chemical Property of 3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol

There total 4 articles about 3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-<(Diphenylphosphanyl)methyl>-3-methyloxetan (157617-59-9) + diphenylphosphane (829-85-6) → 3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol (157617-60-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1.) 23 deg C, 1 h, 2.) reflux, 1 h;

Reference yield: 53.0%

methanesulfonic acid 3-methyloxetan-3-ylmethyl ester (3864-43-5) + diphenylphosphane (829-85-6) → 3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol (157617-60-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; for 6h; Heating;

DOI:10.1039/DT9940003499

Reference yield:

methanesulfonic acid 3-methyloxetan-3-ylmethyl ester (3864-43-5) → 3-(diphenylphosphino)-2-(diphenylphosphino)methyl-2-methylpropanol (157617-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 98percent KOtBu / 1.) THF, 23 deg C, 30 min, 2.) THF, 23 deg C, 14 h

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 30 min, 2.) THF, hexane, reflux, 3 h

With n-butyllithium; potassium tert-butylate;

upstream raw materials:

3-<(Diphenylphosphanyl)methyl>-3-methyloxetan

diphenylphosphane

methanesulfonic acid 3-methyloxetan-3-ylmethyl ester

Downstream raw materials:

[2,2-bis(diphenylphosphinomethyl)propan-1-ol-P,P']tetracarbonylchromium⁽⁰⁾

syn,fac-[2,2-bis(diphenylphosphinomethyl)propan-1-ol-P,P']iodotricarbonylmanganese(I)

anti,fac-[2,2-bis(diphenylphosphinomethyl)propan-1-ol-P,P']iodotricarbonylmanganese(I)

syn,fac-[2,2-bis(diphenylphosphinomethyl)propan-1-ol-P,P']bromotricarbonylmanganese(I)