2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite

Base Information

• Chemical Name: 2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite
• CAS No.: 143538-50-5
• Molecular Formula: C₂₇H₂₇O₆P
• Molecular Weight: 478.482
• Mol file: 143538-50-5.mol

Synonyms:2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite

Chemical Property of 2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite

There total 4 articles about 2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,4,6-tri-O-benzyl-myo-inositol (114828-08-9) → 2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite (143538-50-5)

Guidance literature:

With pyridine; dmap; phosphorus trichloride; at 80 ℃; for 4h;

Reference yield:

meso-2,4,6-tri-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate (114847-11-9) → 2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite (143538-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 36percent aq. HCl / methanol / Heating

2: P(NEt₂)3 / dioxane / 18 h / 110 °C

With hydrogenchloride; hexaethylphosphoric triamide; In 1,4-dioxane; methanol;

Reference yield:

benzyl bromide (100-39-0) → 2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphite (143538-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH, imidazole / dimethylformamide / Ambient temperature

2: 36percent aq. HCl / methanol / Heating

3: P(NEt₂)3 / dioxane / 18 h / 110 °C

With 1H-imidazole; hydrogenchloride; sodium hydride; hexaethylphosphoric triamide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

upstream raw materials:

2,4,6-tri-O-benzyl-myo-inositol

benzyl bromide

meso-2,4,6-tri-O-benzyl-D-myo-inositol-1,3,5-O-orthoformate

Downstream raw materials:

2,4,6-O-tribenzyl myo-inositol-1,3,5-O-phosphate

2,4,6-O-tribenzyl myo-inositol-1,3,5-O-thiophosphate