1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea

Base Information

Chemical Name:1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea
CAS No.:1402581-72-9
Molecular Formula:C₂₃H₂₈ClN₅O₃S
Molecular Weight:490.026
Hs Code.:

Synonyms:1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea

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Chemical Property of 1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea

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Technology Process of 1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea

There total 14 articles about 1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1254713-63-7
(3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methanamine

: 1402586-09-7
phenyl 4-(methylsulfonamidomethyl)phenylcarbamate

: 1402581-72-9
1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea

Guidance literature:: With dmap; In acetonitrile; at 50 ℃; for 15h;

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1402581-72-9
1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

1.2: 1 h / 75 °C

2.1: copper diacetate; pyridine / dichloromethane / 16 h / 23 °C

3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 23 °C

4.1: dmap / acetonitrile / 15 h / 50 °C

With pyridine; hydrogenchloride; dmap; palladium 10% on activated carbon; hydrogen; copper diacetate; sodium nitrite; In methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 598-98-1
Methyl pivalate

: 1402581-72-9
1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-(methanesulfonamidomethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / paraffin oil; 1,4-dioxane / 0.75 h

1.2: 3 h / Reflux

2.1: hydrazine hydrate / ethanol / 3 h / Reflux

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

3.2: 1 h / 75 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 23 °C

4.2: 0.5 h / 100 °C

5.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 23 °C

6.1: dmap / acetonitrile / 15 h / 50 °C

With hydrogenchloride; dmap; palladium 10% on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; sodium nitrite; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; paraffin oil;