benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate

Base Information

Chemical Name:benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate
CAS No.:1413936-70-5
Molecular Formula:C₄₆H₅₃N₅O₈S
Molecular Weight:836.022
Hs Code.:

benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate

Synonyms:benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate

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Chemical Property of benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate

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Technology Process of benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate

There total 4 articles about benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 125483-56-9
benzyl 1-amino-cyclobutanecarboxylate

: 187618-60-6
N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-N^G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine

: 1413936-70-5
benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃;
DOI:10.3762/bjoc.8.142

Reference yield:

: 100-39-0
benzyl bromide

: 1413936-70-5
benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; acetone; acetonitrile;
DOI:10.3762/bjoc.8.142

Reference yield:

: 1164340-01-5
benzyl 1-(tert-butoxycarbonylamino)cyclobutanecarboxylate

: 1413936-70-5
benzyl 1-((((3R)-1-aza-6-(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl)guanidino)-3-(9H-9-fluorenylmethoxycarbonylamido)-2-oxohexanyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.3762/bjoc.8.142