N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester

Base Information

Chemical Name:N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester
CAS No.:404871-49-4
Molecular Formula:C₂₆H₂₆INO₄S
Molecular Weight:575.467
Hs Code.:

Synonyms:N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester

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Chemical Property of N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester

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Technology Process of N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester

There total 6 articles about N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108-98-5
thiophenol

: 404871-46-1
3-[benzyl(2-iodo-4-methoxyphenyl)carbamoyl]but-3-enoic acid methyl ester

: 404871-49-4
N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; Heating;
DOI:10.1039/b108622g

Reference yield:

: 18437-68-8
tert-butyl N-(4-methoxyphenyl)carbamate

: 404871-49-4
N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: t-BuLi / pentane; diethyl ether / 3 h / -20 °C

1.2: 86 percent / 1,2-diiodoethane / pentane; diethyl ether / 16 h / -78 - 20 °C

2.1: 89 percent / CF₃COOH / CH₂Cl₂ / 2 h / 20 °C

3.1: 94 percent / ZnCl₂; NaCNBH₃ / CH₂Cl₂ / 2 h / Heating

4.1: 94 percent / Et₃N / benzene / 2 h

5.1: 96 percent / DBU / tetrahydrofuran / 16 h / Heating

With tert.-butyl lithium; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; pentane; benzene;
DOI:10.1039/b208114h

Reference yield:

: 191348-14-8
2-iodo-4-methoxylaniline

: 404871-49-4
N-benzyl-N-(2-iodo-4-methoxyphenyl)-3-phenylsulfanylmethylsuccinamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / ZnCl₂; NaCNBH₃ / CH₂Cl₂ / 2 h / Heating

2: 94 percent / Et₃N / benzene / 2 h

3: 96 percent / DBU / tetrahydrofuran / 16 h / Heating

With sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; zinc(II) chloride; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1039/b208114h