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18437-68-8

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18437-68-8 Usage

General Description

Tert-Butyl-4-Methoxycarbanilate, often synonymously referred to as Boc-Anisidine, is a chemical compound that has the molecular formula C13H21NO3. It is primarily utilized in the pharmaceutical industry, where it is predominantly used as an intermediate in organic synthesis and during the production of certain types of drugs. This organic compound is documented to be presented as either a solid or as a thick oil-like substance and is distinguished by its distinctive color, which can range from translucent to pale-yellow. As with any chemical, safety measures would need to be in place during its use, as exposure can cause skin irritation and serious eye damage.

Check Digit Verification of cas no

The CAS Registry Mumber 18437-68-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,4,3 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18437-68:
(7*1)+(6*8)+(5*4)+(4*3)+(3*7)+(2*6)+(1*8)=128
128 % 10 = 8
So 18437-68-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO3/c1-12(2,3)16-11(14)13-9-5-7-10(15-4)8-6-9/h5-8H,1-4H3,(H,13,14)

18437-68-8 Well-known Company Product Price

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  • Aldrich

  • (768715)  N-Boc-4-methoxyaniline  97%

  • 18437-68-8

  • 768715-1G

  • 453.96CNY

  • Detail
  • Aldrich

  • (768715)  N-Boc-4-methoxyaniline  97%

  • 18437-68-8

  • 768715-5G

  • 1,512.81CNY

  • Detail

18437-68-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-(4-methoxyphenyl)carbamate

1.2 Other means of identification

Product number -
Other names tert-butyl 4-methoxyphenylcarbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18437-68-8 SDS

18437-68-8Relevant articles and documents

Chiral Phosphoric Acid Catalyzed Asymmetric Desymmetrization of para-Quinamines with Isocyanates: Access to Functionalized Imidazolidin-2-one Derivatives

Hu, Kai-Wen,You, Xiao,Wang, Jin-Zheng,Wen, Xiaoan,Sun, Hongbin,Xu, Qing-Long,Lai, Zengwei

supporting information, p. 7873 - 7877 (2021/10/20)

The development of enantioselective desymmetrization of para-quinamines with isocyanates catalyzed by chiral phosphoric acid is reported. The strategy provides concise access to functionalized imidazolidin-2-one derivatives in high yields and enantioselectivities under mild reaction conditions. Remarkably, this reaction could be performed on a gram scale using 5 mol % catalyst loading and the chiral imidazolidin-2-one derivatives could be easily transformed into valuable scaffolds without disturbing the enantiopurity, demonstrating the synthetic utility of this protocol.

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Ingale, Ajit P.,Shinde, Sandeep V.,Thorat, Nitin M.

supporting information, p. 2528 - 2543 (2021/07/02)

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Base-Mediated Generation of Ketenimines from Ynamides: [3+2] Annulation with Azaallyl Anions

D'Hollander, Agathe C. A.,Romero, Eugénie,Vijayakumar, Kamsana,Le Houérou, Camille,Retailleau, Pascal,Dodd, Robert H.,Iorga, Bogdan I.,Cariou, Kevin

supporting information, p. 2903 - 2908 (2021/04/21)

Under basic conditions and heat, ynamides can serve as precursors to ketenimines, whose synthetic potential is often hampered by their difficulty of access. Herein, we report that they can undergo a [3+2] cycloaddition with 2-azaallyl anions, obtained from benzylimines under the same reaction conditions. This reaction between two highly reactive intermediates, both generated in situ from bench stable starting materials, gives access to various nitrogen-rich heterocycles. The reaction usually proceeds with excellent diastereoselectivity, in favor of the cis adduct. Deuteration experiments and DFT calculations helped rationalize the regio- and stereoselectivity of the process as well as the formation of side products. (Figure presented.).

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