(+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester

Base Information

Chemical Name:(+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester
CAS No.:218450-15-8
Molecular Formula:C₁₇H₁₂F₂N₂O₆
Molecular Weight:378.289
Hs Code.:

Synonyms:(+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester

Suppliers and Price of (+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester

There total 6 articles about (+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 218450-05-6
(4S,5S)-4-(3,4-difluorophenyl)-5-methyloxazolidin-2-one

: 218450-15-8
(+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester

Guidance literature:: (4S,5S)-4-(3,4-difluorophenyl)-5-methyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

4-Nitrophenyl chloroformate; In tetrahydrofuran; hexane; for 1h; Further stages.;
DOI:10.1021/jm000085e

Reference yield:

: 328387-94-6
(S)-1-Amino-1-(3,4-difluoro-phenyl)-propan-2-ol

: 218450-15-8
(+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CHCl₃

2: NaH / tetrahydrofuran

3: NaH

With sodium hydride; In tetrahydrofuran; chloroform;
DOI:10.1016/S0960-894X(00)00524-2

Reference yield:

: [1-(3,4-difluoro-phenyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

: 218450-15-8
(+)-4-(S)-(3,4-difluorophenyl)-5-(S)-methyl-2-oxo-oxazolidine-3-carboxylic acid-4-nitrophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran

2: NaH

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(00)00524-2