3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid

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Chemical Name:3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid
CAS No.:1356598-73-6
Molecular Formula:C₂₈H₂₆N₂O₆
Molecular Weight:486.524
Hs Code.:

Synonyms:3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid

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Chemical Property of 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid

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Technology Process of 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid

There total 9 articles about 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.5%

: 1356600-16-2
methyl 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoate

: 1356598-73-6
3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid

Guidance literature:: methyl 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water; at 0 ℃; pH=3;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1356598-73-6
3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; acetic acid / 0.08 h / 20 °C

1.2: 3 h / 20 - 80 °C

2.1: potassium carbonate / acetonitrile / 0.08 h / 20 °C

2.2: 5 h / 20 - 80 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 10.33 h / 0 - 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

4.2: 0 °C / pH 3

With water; sodium acetate; potassium carbonate; acetic acid; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 501-98-4,4501-31-9,7400-08-0,50940-26-6
(Z)-p-coumaric acid

: 1356598-73-6
3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 85 °C / Inert atmosphere

2.1: N,N,N',N'-tetramethylguanidine / 11 h / 50 - 100 °C

3.1: triethylamine; 1,4-diisocyanatobenzene / 8 h / 85 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

5.1: methanesulfonic acid / 2 h / 0 °C / Reflux

6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 10.33 h / 0 - 20 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

7.2: 0 °C / pH 3

With methanesulfonic acid; water; potassium carbonate; 1,4-diisocyanatobenzene; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;