2-(Pyridin-3-yl)quinazolin-4-amine

Base Information

• Chemical Name: 2-(Pyridin-3-yl)quinazolin-4-amine
• CAS No.: 273408-90-5
• Molecular Formula: C13H10 N4
• Molecular Weight: 222.249
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10390020
• Nikkaji Number: J1.283.014I
• Wikidata: Q82186386
• Mol file: 273408-90-5.mol

Synonyms:2-(pyridin-3-yl)quinazolin-4-amine;273408-90-5;2-Pyridin-3-yl-quinazolin-4-ylamine;2-pyridin-3-ylquinazolin-4-amine;SCHEMBL13272569;DTXSID10390020;2-(3-Pyridinyl)quinazoline-4-amine;AKOS000674119;WAY-311134;AC-17182;BB 0262391;CS-0336080;2-pyridin-3-yl-quinazolin-4-ylamine, AldrichCPR;A923882;SR-01000362497;SR-01000362497-1;BRD-K93327825-001-01-1

Chemical Property of 2-(Pyridin-3-yl)quinazolin-4-amine

Chemical Property:

• Vapor Pressure: 3.87E-05mmHg at 25°C
• Melting Point: 185-188 °C
• Refractive Index: 1.716
• Boiling Point: 352.3°C at 760 mmHg
• PKA: 4.71±0.30(Predicted)
• Flash Point: 194°C
• PSA: 64.69000
• Density: 1.301g/cm³
• LogP: 2.85520
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 222.090546336
• Heavy Atom Count: 17
• Complexity: 258

Purity/Quality:

97% ^*data from raw suppliers

2-Pyridin-3-yl-quinazolin-4-ylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=NC(=N2)C3=CN=CC=C3)N

Technology Process of 2-(Pyridin-3-yl)quinazolin-4-amine

There total 6 articles about 2-(Pyridin-3-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

pyridine-3-carbonitrile (100-54-9,121697-66-3,1232169-17-3,68271-95-4) + anthranilic acid nitrile (1885-29-6) → 4-amino-2-(pyridin-3-yl)quinazoline (273408-90-5)

Guidance literature:

anthranilic acid nitrile; With sodium hydride; In tetrahydrofuran; at 0 ℃;

pyridine-3-carbonitrile; In tetrahydrofuran; for 20h; Further stages.; Heating;

DOI:10.1021/jm000002u

Reference yield: 77.0%

3-pyridinecarboxaldehyde (500-22-1) + o-cyanobromobenzene (2042-37-7) → 4-amino-2-(pyridin-3-yl)quinazoline (273408-90-5)

Guidance literature:

With iron(III) chloride; copper(l) iodide; sodium azide; L-proline; In N,N-dimethyl-formamide; at 110 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.5b02020

Reference yield: 75.0%

3-pyridinecarboxaldehyde (500-22-1) + 2-iodobenzimidamide (885953-16-2) → 4-amino-2-(pyridin-3-yl)quinazoline (273408-90-5)

Guidance literature:

With sodium azide; L-proline; copper(I) bromide; In N,N-dimethyl-formamide; at 70 ℃;

DOI:10.1055/s-0036-1588727

upstream raw materials:

pyridine-3-carbonitrile

anthranilic acid nitrile

nicotinic acid

3-pyridinecarboxaldehyde

Downstream raw materials:

VUF 5574