1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane

Base Information

Chemical Name:1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane
CAS No.:110476-91-0
Molecular Formula:C₂₇H₃₀Cl₂N₂O₆
Molecular Weight:549.451
Hs Code.:

1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane

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Chemical Property of 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane

Chemical Property:

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Technology Process of 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane

There total 5 articles about 1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101411-65-8
1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne

: 110476-91-0
1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / HgSO₄, conc. H₂SO₄ / dioxane; H₂O / 2 h / 60 °C

2: 41 percent / NaBH₄ / ethanol / 5 h / Ambient temperature

3: 1.) n-BuLi / 1.) hexane, THF, RT, 50 min, 2.) -70 deg C, 2 h

With sodium tetrahydroborate; n-butyllithium; sulfuric acid; mercury(II) sulfate; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm00105a004

Reference yield:

: 101411-57-8
4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine

: 110476-91-0
1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / NaBH₄ / ethanol / 5 h / Ambient temperature

2: 1.) n-BuLi / 1.) hexane, THF, RT, 50 min, 2.) -70 deg C, 2 h

With sodium tetrahydroborate; n-butyllithium; In ethanol;
DOI:10.1021/jm00105a004

Reference yield:

: 90445-15-1
2-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy}acetic acid

: 110476-91-0
1-{[4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-5-methoxy-carbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}-2-hydroxy-2-(2-pyridylmethyl)propane

Guidance literature:: Multi-step reaction with 3 steps

2: 41 percent / NaBH₄ / ethanol / 5 h / Ambient temperature

3: 1.) n-BuLi / 1.) hexane, THF, RT, 50 min, 2.) -70 deg C, 2 h

With sodium tetrahydroborate; n-butyllithium; In ethanol;
DOI:10.1021/jm00105a004