(E)-ethyl 3-(2,4-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

Base Information

• Chemical Name: (E)-ethyl 3-(2,4-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate
• CAS No.: 1610688-75-9
• Molecular Formula: C₁₆H₁₆Cl₂N₂O₃
• Molecular Weight: 355.221
• Mol file: 1610688-75-9.mol

Synonyms:(E)-ethyl 3-(2,4-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

Chemical Property of (E)-ethyl 3-(2,4-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (E)-ethyl 3-(2,4-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

There total 1 articles about (E)-ethyl 3-(2,4-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (100726-70-3) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (E)-ethyl 3-(2,4-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (1610688-75-9)

Guidance literature:

With 1-methyl-1H-imidazole; at 80 ℃; for 6h;

DOI:10.1016/j.tet.2014.04.015

Reference yield: 64.0%

(E)-ethyl 3-(2,4-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (1610688-75-9) → diethyl 5,5'-(4-(dimethylamino)buta-1,3-diene-1,3-diyl)bis(3-(2,4-dichlorophenyl)isoxazole-4-carboxylate) (1610688-82-8) + triethyl 5,5',5-(benzene-1,3,5-triyl)tris(3-(2,4-dichlorophenyl)isoxazole-4-carboxylate) (1610688-90-8)

Guidance literature:

With acetyl chloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.tet.2014.04.015

upstream raw materials:

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

diethyl 5,5'-(4-(dimethylamino)buta-1,3-diene-1,3-diyl)bis(3-(2,4-dichlorophenyl)isoxazole-4-carboxylate)

triethyl 5,5',5-(benzene-1,3,5-triyl)tris(3-(2,4-dichlorophenyl)isoxazole-4-carboxylate)