methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate

Base Information

Chemical Name:methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate
CAS No.:1307853-72-0
Molecular Formula:C₃₀H₂₈N₆O₃
Molecular Weight:520.591
Hs Code.:

Synonyms:methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate

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Chemical Property of methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate

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Technology Process of methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate

There total 12 articles about methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307853-71-9
methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate

: 1307853-72-0
methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate

Guidance literature:: With tin(II) chloride dihdyrate; In methanol; for 2h; Reflux;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1307853-72-0
methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice

1.2: 1 h

2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1.5 h / 20 °C

4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C

5.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere

6.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C

7.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; tetrabutylammomium bromide; sodium methylate; phosphorus tribromide; sodium carbonate; potassium carbonate; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; chloroform; water; acetonitrile;

Reference yield:

: 18039-42-4,3999-10-8
5-Phenyl-1H-tetrazole

: 1307853-72-0
methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice

1.2: 1 h

2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1.5 h / 20 °C

4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C

5.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere

6.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C

7.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; tetrabutylammomium bromide; sodium methylate; phosphorus tribromide; sodium carbonate; potassium carbonate; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; chloroform; water; acetonitrile;