(+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile

Base Information

• Chemical Name: (+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile
• CAS No.: 116078-67-2
• Molecular Formula: C₂₂H₂₉ClF₃N₃O
• Molecular Weight: 443.94
• Mol file: 116078-67-2.mol

Synonyms:(+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile

Chemical Property of (+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile

There total 6 articles about (+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide (116078-64-9) + trifluoroacetic anhydride (407-25-0) → (+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile (116078-67-2)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 1h;

DOI:10.1021/jm00119a017

Reference yield:

2-(piperidin-4-yl)ethyl chloride (1932-03-2) → (+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile (116078-67-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 38 percent / sodamide / toluene / 1.5 h / 80 °C

2: NaNH₂ / toluene / 2 h / 90 °C

3: 87 percent / conc. H₂SO₄ / 2.5 h / 95 - 100 °C

4: 91 percent / conc. HCl, H₃PO₄, hydrogen / Pd/BaSO₄ / ethanol / 5 h / 25 °C / 4116.5 Torr

5: 41 percent / Et₃N / CHCl₃ / 1 h / 0 °C

With hydrogenchloride; phosphoric acid; sulfuric acid; hydrogen; sodium amide; triethylamine; Pd-BaSO₄; In ethanol; chloroform; toluene;

DOI:10.1021/jm00119a017

Reference yield:

2-Chlorophenylacetonitrile (2856-63-5) → (+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile (116078-67-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 38 percent / sodamide / toluene / 1.5 h / 80 °C

2: NaNH₂ / toluene / 2 h / 90 °C

3: 87 percent / conc. H₂SO₄ / 2.5 h / 95 - 100 °C

4: 91 percent / conc. HCl, H₃PO₄, hydrogen / Pd/BaSO₄ / ethanol / 5 h / 25 °C / 4116.5 Torr

5: 41 percent / Et₃N / CHCl₃ / 1 h / 0 °C

With hydrogenchloride; phosphoric acid; sulfuric acid; hydrogen; sodium amide; triethylamine; Pd-BaSO₄; In ethanol; chloroform; toluene;

DOI:10.1021/jm00119a017

upstream raw materials:

α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide

trifluoroacetic anhydride

2-(piperidin-4-yl)ethyl chloride

2-Chlorophenylacetonitrile