(1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1356336-78-1
Molecular Formula:C₂₈H₃₃NO₅S
Molecular Weight:495.64
Hs Code.:

Synonyms:(1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about (1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1356336-76-9
(1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1356336-78-1
(1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: formaldehyd; (1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; With formic acid; In water; at 90 ℃; for 2h;

With sodium hydrogencarbonate; In water; at 25 ℃; pH=> 7;
DOI:10.1016/j.tet.2011.11.046

Reference yield:

: C₁₈H₂₀ClNO₃S

: 1356336-78-1
(1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere

3.1: formic acid / water / 2 h / 90 °C

3.2: 25 °C / pH > 7

With formic acid; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; water; 3.1: Eschweiler-Clarke reaction;
DOI:10.1016/j.tet.2011.11.046

Reference yield:

: 1356336-74-7
(1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-dimethoxy-2-(S)-p-tolylsulfinyl-1,2,3,4-tetrahydroisoquinoline

: 1356336-78-1
(1S)-1-(3,4-dimethoxy-2-(S)-(p-tolylsulfinyl)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere

2.1: formic acid / water / 2 h / 90 °C

2.2: 25 °C / pH > 7

With formic acid; trifluoroacetic acid; In methanol; water; 2.1: Eschweiler-Clarke reaction;
DOI:10.1016/j.tet.2011.11.046