2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide

Base Information

Chemical Name:2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide
CAS No.:1033624-53-1
Molecular Formula:C₂₃H₁₈F₅N₃O₃S
Molecular Weight:511.472
Hs Code.:

Synonyms:2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide

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Chemical Property of 2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide

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Technology Process of 2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide

There total 6 articles about 2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 2,2-difluoro-2-(4-(trifluoromethyl)phenoxy)acetic acid

: 3',4'-diamino-N,N-dimethylbiphenyl-2-sulfonamide

: 1033624-53-1
2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide

Guidance literature:: With hydrogenchloride; In water; at 110 ℃; for 16h;
DOI:10.1021/acs.orglett.6b03730

Reference yield:

: 65000-13-7
2-bromo-N,N-dimethylbenzenesulfonamide

: 1033624-53-1
2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,2-dimethoxyethane / 16 h / 100 °C / Inert atmosphere

2: hydrogenchloride / methanol; diethyl ether / 4 h / 20 °C

3: hydrogenchloride / water / 16 h / 110 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In methanol; 1,2-dimethoxyethane; diethyl ether; water;
DOI:10.1021/acs.orglett.6b03730

Reference yield:

: ethyl 2-(4-(trifluoromethyl)phenoxy)-2,2-difluoro acetate

: 1033624-53-1
2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; acetonitrile / 3 h / 20 °C

2: hydrogenchloride / water / 16 h / 110 °C

With hydrogenchloride; sodium hydroxide; In water; acetonitrile;
DOI:10.1021/acs.orglett.6b03730