65000-13-7

Usage

Uses

Used in Chemical Synthesis:
2-Bromo-N,N-dimethylbenzenesulphonamide is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure, including the bromine atom, allows it to participate in a range of chemical reactions, facilitating the creation of new molecules with potential applications in different industries.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-Bromo-N,N-dimethylbenzenesulphonamide is used as a building block for the development of therapeutic drugs. Its presence in benzenesulfonamide-based compounds makes it a candidate for medicinal chemistry, where it can be modified or used as a precursor to create pharmaceutical agents with specific therapeutic effects.
Used in Research and Development:
2-Bromo-N,N-dimethylbenzenesulphonamide is also utilized in research settings to study the properties and reactivity of halogenated benzenesulfonamides. Its use in academic and industrial research helps to expand the understanding of chemical behavior and to develop new methodologies and applications in organic chemistry.
While the specific uses and properties of 2-Bromo-N,N-dimethylbenzenesulphonamide may vary depending on the context, its role in chemical synthesis, pharmaceutical development, and research underscores its importance in the broader field of chemistry. Further exploration and application of 2-Bromo-N,N-dimethylbenzenesulphonamide may lead to new discoveries and advancements in related industries.

InChI:InChI=1/C8H10BrNO2S/c1-10(2)13(11,12)8-6-4-3-5-7(8)9/h3-6H,1-2H3

Upstream product

• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 124-40-3 dimethyl amine 
• 103-83-3 N,N'-dimethylbenzylamine 
• 60199-33-9 ortho-bromobenzenesulfonyl hydrazide 
• 75-50-3 trimethylamine 
• 92748-09-9 2-bromobenzene-1-sulfonamide 
• 74-88-4 methyl iodide 

Downstream Products

• 1240264-27-0 [(C₆H₄S(O)2NMe₂)Pd(bromide)(PCy₃)2] 
• 51119-86-9 o-ethenyl-N,N-dimethylbenzenesulfonamide 
• 1033624-53-1 2-(2-{difluoro[4-(trifluoromethyl)phenoxy]methyl}-1H-benzimidazol-5-yl)-N,N-dimethylbenzenesulfonamide 

Relevant academic research and scientific papers

An approach to C-N activation: Coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with: Tert -amines via a metal-, oxidant- and halogen-free anodic oxidation

tert-Amines were harnessed to afford arenesulfonyl hydrazides and arenesulfonyl chlorides via a metal-, oxidant- and halogen-free electrochemical oxidative coupling in an undivided cell at RT. This environmentally benign approach afforded a wide spectrum of sulfonamides in satisfactory yields using cheap and renewable Pencil Graphite Electrodes (PGEs).

Synthesis and Reactivity of 18F-Labeled α,α-Difluoro-α-(aryloxy)acetic Acids

In this work, we describe the 18F-labeling of α,α-difluoro-α-(aryloxy)acetic acid derivatives and demonstrate that these building blocks are amenable to post-18F-fluorination functionalization. Protodecarboxylation offers a new entry to 18F-difluoromethoxyarene, and the value of this approach is further demonstrated with coupling processes leading to representative 18F-labeled TRPV1 inhibitors and TRPV1 antagonists.

Ruthenium olefin metathesis catalysts containing six-membered sulfone and sulfonamide chelating rings

The preparation and X-ray structure characterization of new olefin metathesis initiators containing sulfone- and sulfonamide-substituted benzylidene ligands are described. We observed that these catalysts exhibit Ru???O(SO)R interactions, forming six-memb

Investigation of the mechanism of C(sp3)-H bond cleavage in Pd(0)-catalyzed intramolecular alkane arylation adjacent to amides and sulfonamides

The reactivity of C(sp3)-H bonds adjacent to a nitrogen atom can be tuned to allow intramolecular alkane arylation under Pd(0) catalysis. Diminishing the Lewis basicity of the nitrogen lone pair is crucial for this catalytic activity. A range of N-methylamides and sulfonamides react exclusively at primary C(sp3)-H bonds to afford the products of alkane arylation in good yields. The isolation of a Pd(II) reaction intermediate has enabled an evaluation of the reaction mechanism with a focus on the role of the bases in the C(sp3)-H bond cleaving step. The results of these stoichiometric studies, together with kinetic isotope effect experiments, provide rare experimental support for a concerted metalation-deprotonation (CMD) transition state, which has previously been proposed in alkane C(sp3)-H arylation. Moreover, DFT calculations have uncovered the additional role of the pivalate additive as a promoter of phosphine dissociation from the Pd(II) intermediate, enabling the CMD transition state. Finally, kinetic studies were performed, revealing the reaction rate expression and its relationship with the concentration of pivalate.

AMINOQUINAZOLINES COMPOUNDS

The present invention is concerned with compounds of formula (1), wherein R1, R2 and X are as defined in the description and claims. The compounds of the present invention are PTP-1B inhibitors and can be used as medicaments.