(E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide

Base Information

• Chemical Name: (E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide
• CAS No.: 1319729-48-0
• Molecular Formula: C₁₅H₁₅N₃S₂
• Molecular Weight: 301.436
• Mol file: 1319729-48-0.mol

Synonyms:(E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide

Chemical Property of (E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide

There total 2 articles about (E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-Phenyl-3-thiosemicarbazide (5351-69-9) + 4-(Methylthio)benzaldehyde (3446-89-7) → (E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide (1319729-48-0)

Guidance literature:

With acetic acid; In ethanol; for 2h; Reflux;

DOI:10.3390/molecules19033068

Reference yield:

phenyl isothiocyanate (103-72-0) → (E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide (1319729-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 20 °C

2: acetic acid / ethanol / 2 h / Reflux

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.3390/molecules19033068

Reference yield: 90.0%

(E)-2-(4-(methylthio)benzylidene)-N-phenylhydrazinecarbothioamide (1319729-48-0) + ethyl bromoacetate (105-36-2) → 2-((E)-(4-(methylthio)benzylidene)hydrazono)-3-phenylthiazolidin-4-one

Guidance literature:

With sodium acetate; In ethanol; for 3h; Reflux;

DOI:10.3390/molecules19033068

upstream raw materials:

4-Phenyl-3-thiosemicarbazide

4-(Methylthio)benzaldehyde

phenyl isothiocyanate