Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester

Base Information

Chemical Name:Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester
CAS No.:215546-05-7
Molecular Formula:C₂₁H₃₂O₂Si
Molecular Weight:344.569
Hs Code.:

Synonyms:Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester

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Technology Process of Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester

There total 7 articles about Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 108-24-7
acetic anhydride

: 215546-37-5
(E)-5-Cyclohexyl-5-(dimethyl-phenyl-silanyl)-pent-3-en-2-ol

: 215546-05-7
Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester

Guidance literature:: With dmap; triethylamine; In diethyl ether; at 20 ℃;

Reference yield:

: 931-50-0
cyclohexylmagnesium bromide

: 215546-05-7
Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) CuI, 2.) NaCN, NH₄Cl, H₂O / 1.) Et₂O, 20-30 deg C, 30 min, 2.) Et₂O, 40 min

2: 91 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -45 deg C, 1 h, 2.) -45 to 20 deg C, 1 h

3: 83 percent / t-BuLi, TMEDA / hexane; tetrahydrofuran / 1.) -70 deg C, 15 min; -70 to 0 deg C, 1 h, 2.) -70 deg C, 15 min; -70 to 20 deg C, 75 min

4: 1.) AgNO₃, 2.) KCN / 1.) EtOH, H₂O, 0-5 deg C, 15 min, 2.) EtOH, H₂O, 20 deg C, 2 h

5: 51 percent / n-BuLi / diethyl ether; hexane / 1.) 0 deg C, 75 min, 2.) 30 min

6: 46 percent / LiAlH₄, MeOH / tetrahydrofuran / 5 h / Heating

7: 89 percent / DMAP, Et₃N / diethyl ether / 20 °C

With methanol; dmap; potassium cyanide; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium cyanide; water; tert.-butyl lithium; ammonium chloride; silver nitrate; triethylamine; In tetrahydrofuran; diethyl ether; hexane;

Reference yield:

: 17715-00-3
prop-2-ynylcyclohexane

: 215546-05-7
Acetic acid (E)-4-cyclohexyl-4-(dimethyl-phenyl-silanyl)-1-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -45 deg C, 1 h, 2.) -45 to 20 deg C, 1 h

2: 83 percent / t-BuLi, TMEDA / hexane; tetrahydrofuran / 1.) -70 deg C, 15 min; -70 to 0 deg C, 1 h, 2.) -70 deg C, 15 min; -70 to 20 deg C, 75 min

3: 1.) AgNO₃, 2.) KCN / 1.) EtOH, H₂O, 0-5 deg C, 15 min, 2.) EtOH, H₂O, 20 deg C, 2 h

4: 51 percent / n-BuLi / diethyl ether; hexane / 1.) 0 deg C, 75 min, 2.) 30 min

5: 46 percent / LiAlH₄, MeOH / tetrahydrofuran / 5 h / Heating

6: 89 percent / DMAP, Et₃N / diethyl ether / 20 °C

With methanol; dmap; potassium cyanide; lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; silver nitrate; triethylamine; In tetrahydrofuran; diethyl ether; hexane;