tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane

Base Information

• Chemical Name: tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane
• CAS No.: 936856-43-8
• Molecular Formula: C₁₄H₂₃ClO₂Si
• Molecular Weight: 286.874
• Mol file: 936856-43-8.mol

Synonyms:tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane

Chemical Property of tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane

There total 4 articles about tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)methanol (936856-34-7) → tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane (936856-43-8)

Guidance literature:

With thionyl chloride; In toluene; at 20 ℃; for 18h;

DOI:10.1021/ja068189n

Reference yield:

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) → tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane (936856-43-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / imidazole / dimethylformamide / 1 h / 20 °C

2: 68 percent / NaBH₄ / methanol / 2 h / 20 °C

3: 94 percent / thionyl chloride / toluene / 18 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja068189n

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl-(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane (936856-43-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / imidazole / dimethylformamide / 1 h / 20 °C

2: 68 percent / NaBH₄ / methanol / 2 h / 20 °C

3: 94 percent / thionyl chloride / toluene / 18 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja068189n

upstream raw materials:

(2-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)methanol

2-Hydroxy-4-methoxybenzaldehyde

tert-butyldimethylsilyl chloride

2-((tert-butyldimethylsilyl)oxy)-4-methoxybenzaldehyde

Downstream raw materials:

1-(2-bromo-3,5-dimethoxyphenyl)-2-(2-hydroxy-4-methoxyphenyl)ethanone

(R)-8-methoxy-4-phenyl-4,5-dihydrobenzo[b]oxepin-2(3H)-one

(3S)-2'-hydroxy-4',7-dimethoxyisoflavan

(3R)-2'-hydroxy-4',7-dimethoxyisoflavan