Technology Process of 7-chloro-6-O-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole
There total 8 articles about 7-chloro-6-O-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 67 percent / AlCl3 / 1,2-dichloro-ethane / 1.) from 5 deg C to RT, 30 min, 2.) reflux, 30 min
2: 76 percent / hydroxylamine hydrochloride, pyridine / 24 h / Heating
3: 98 percent / 1 h / Heating
4: 84 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C
5: 91 percent / pyridine hydrochloride / 2 h / 180 °C
6: 1.) sodium hydride (50percent suspension in oil) / 1.) DMF, RT, 1 h, 2.) 60 deg C, 2.5 h
With
pyridine; aluminium trichloride; hydroxylamine hydrochloride; pyridine hydrochloride; sodium hydride;
In
1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / hydroxylamine hydrochloride, pyridine / 24 h / Heating
2: 98 percent / 1 h / Heating
3: 84 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C
4: 91 percent / pyridine hydrochloride / 2 h / 180 °C
5: 1.) sodium hydride (50percent suspension in oil) / 1.) DMF, RT, 1 h, 2.) 60 deg C, 2.5 h
With
pyridine; hydroxylamine hydrochloride; pyridine hydrochloride; sodium hydride;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / 1 h / Heating
2: 84 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C
3: 91 percent / pyridine hydrochloride / 2 h / 180 °C
4: 1.) sodium hydride (50percent suspension in oil) / 1.) DMF, RT, 1 h, 2.) 60 deg C, 2.5 h
With
pyridine hydrochloride; sodium hydride;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008
