7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole

Base Information

Chemical Name:7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole
CAS No.:72482-22-5
Molecular Formula:C₁₆H₁₂ClFN₂O₂S
Molecular Weight:350.801
Hs Code.:

Synonyms:7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole

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Chemical Property of 7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole

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Technology Process of 7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole

There total 9 articles about 7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 72482-21-4
7-chloro-6-O-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole

: 72482-22-5
7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole

Guidance literature:: at 205 ℃; for 0.75h;
DOI:10.1021/jm00343a008

Reference yield:

: 7051-15-2
2-chlororesorcinol dimethyl ether

: 72482-22-5
7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 7 steps

1: 67 percent / AlCl₃ / 1,2-dichloro-ethane / 1.) from 5 deg C to RT, 30 min, 2.) reflux, 30 min

2: 76 percent / hydroxylamine hydrochloride, pyridine / 24 h / Heating

3: 98 percent / 1 h / Heating

4: 84 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C

5: 91 percent / pyridine hydrochloride / 2 h / 180 °C

6: 1.) sodium hydride (50percent suspension in oil) / 1.) DMF, RT, 1 h, 2.) 60 deg C, 2.5 h

7: 80 percent / 0.75 h / 205 °C

With pyridine; aluminium trichloride; hydroxylamine hydrochloride; pyridine hydrochloride; sodium hydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008

Reference yield:

: 72482-07-6
3-chloro-2'-fluoro-2-hydroxy-4-methoxybenzophenone

: 72482-22-5
7-chloro-6-S-(N,N-dimethylthiocarbamyl)-3-(2-fluorophenyl)-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / hydroxylamine hydrochloride, pyridine / 24 h / Heating

2: 98 percent / 1 h / Heating

3: 84 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C

4: 91 percent / pyridine hydrochloride / 2 h / 180 °C

5: 1.) sodium hydride (50percent suspension in oil) / 1.) DMF, RT, 1 h, 2.) 60 deg C, 2.5 h

6: 80 percent / 0.75 h / 205 °C

With pyridine; hydroxylamine hydrochloride; pyridine hydrochloride; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008