2-(2,2-bis(phenylsulfonyl)vinyl)thiophene

Base Information

• Chemical Name: 2-(2,2-bis(phenylsulfonyl)vinyl)thiophene
• CAS No.: 1072831-43-6
• Molecular Formula: C₁₈H₁₄O₄S₃
• Molecular Weight: 390.505
• Mol file: 1072831-43-6.mol

Synonyms:2-(2,2-bis(phenylsulfonyl)vinyl)thiophene

Chemical Property of 2-(2,2-bis(phenylsulfonyl)vinyl)thiophene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(2,2-bis(phenylsulfonyl)vinyl)thiophene

There total 1 articles about 2-(2,2-bis(phenylsulfonyl)vinyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiophene-2-carbaldehyde (98-03-3) + bis(phenylsulfonyl)methane (3406-02-8) → 2-(2,2-bis(phenylsulfonyl)vinyl)thiophene (1072831-43-6)

Guidance literature:

With potassium fluoride; diethyl amine hydrochloride; In toluene; for 24h; Reflux; Dean-Stark;

DOI:10.1002/ejoc.201801504

Reference yield: 90.0%

2-(2,2-bis(phenylsulfonyl)vinyl)thiophene (1072831-43-6) + propionaldehyde (123-38-6) → (2S,3R)-2-methyl-4,4-bis(phenylsulfonyl)-3-(thiophen-2-yl)butan-1-ol (1072831-51-6) + 2-methyl-4,4-bis(phenylsulfonyl)-3-(thiophen-2-yl)butan-1-ol

Guidance literature:

2-(2,2-bis(phenylsulfonyl)vinyl)thiophene; propionaldehyde; With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; In chloroform; at 0 ℃; for 16h;

With sodium tetrahydroborate; In methanol; at 0 ℃; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol8019296

Reference yield: 90.0%

2-(2,2-bis(phenylsulfonyl)vinyl)thiophene (1072831-43-6) + 5H-5-methyl-2-phenyl-2-oxazol-4-one (672963-88-1) → C28H23NO6S3

Guidance literature:

With C₃₀H₃₀F₆N₄OS; In diethyl ether; at 0 ℃; for 50h; enantioselective reaction;

DOI:10.1002/adsc.201400649

upstream raw materials:

thiophene-2-carbaldehyde

bis(phenylsulfonyl)methane

Downstream raw materials:

(2S,3R)-2-methyl-4,4-bis(phenylsulfonyl)-3-(thiophen-2-yl)butan-1-ol