4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide

Base Information

Chemical Name:4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide
CAS No.:170804-83-8
Molecular Formula:C₁₉H₂₁ClN₂O₃
Molecular Weight:360.84
Hs Code.:

Synonyms:4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide

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Chemical Property of 4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide

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Technology Process of 4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide

There total 2 articles about 4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 170804-78-1
4-benzyl-2-morpholineacetic acid hydrochloride

: 95-85-2
2-hydroxy-5-chloro-aniline

: 170804-83-8
4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 6h; Ambient temperature;
DOI:10.1016/0223-5234(96)88276-6

Reference yield:

: 73933-19-4
ethyl 4-(phenylmethyl)-2-morpholineacetate

: 170804-83-8
4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 20percent aq. HCl / 6 h / Heating

2: 55 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 6 h / Ambient temperature

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/0223-5234(96)88276-6

Reference yield:

: 170804-83-8
4-benzyl-N-(5-chloro-2-hydroxyphenyl)-2-morpholineacetamide

: N-(4-Acetylamino-5-chloro-2-ethoxy-phenyl)-2-(4-benzyl-morpholin-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, RT, 6 h

2: conc. H₂SO₄, HNO₃ / acetic acid / 3 h / Ambient temperature

3: 76 percent / SnCl₂, conc. HCl / acetic acid / 15 h / Ambient temperature

4: 81 percent / 20 h / Ambient temperature

With hydrogenchloride; sulfuric acid; nitric acid; sodium hydride; tin(ll) chloride; In acetic acid;
DOI:10.1016/0223-5234(96)88276-6