Ethyl 2-(4-benzylmorpholin-2-yl)acetate

Base Information

• Chemical Name: Ethyl 2-(4-benzylmorpholin-2-yl)acetate
• CAS No.: 73933-19-4
• Molecular Formula: 15H21NO3
• Molecular Weight: 263.337
• DSSTox Substance ID: DTXSID00503329
• Nikkaji Number: J684.777C
• Mol file: 73933-19-4.mol

Synonyms:73933-19-4;Ethyl 2-(4-benzylmorpholin-2-yl)acetate;(4-BENZYL-MORPHOLIN-2-YL)-ACETIC ACID ETHYL ESTER;N-BENZYL-2-ETHOXYCARBONYLMETHYLMORPHOLINE;ethyl (4-benzylmorpholin-2-yl)acetate;Ethyl (4-benzyl-2-morpholinyl)acetate;SCHEMBL7366530;DTXSID00503329;WZFOBUJYPANZMG-UHFFFAOYSA-N;YCA93319;AB1420;MFCD06658438;AKOS015951448;SB38520;Ethyl2-(4-benzylmorpholin-2-yl)acetate;2-ethoxycarbonylmethyl-4-benzylmorpholine;AS-44573;ethyl 4-(phenylmethyl)-2-morpholineacetate;SodiumhydrogenN-(1-oxododecyl)-L-glutamate;CS-0315621;FT-0742455;N-Benzyl-morpholine-2-yl-acetic acid, racemate;A837970

Chemical Property of Ethyl 2-(4-benzylmorpholin-2-yl)acetate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.519
• Boiling Point: 349.144 °C at 760 mmHg
• PKA: 6.25±0.10(Predicted)
• Flash Point: 164.957 °C
• Density: 1.093 g/cm³
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 263.15214353
• Heavy Atom Count: 19
• Complexity: 277

Purity/Quality:

97% ^*data from raw suppliers

(4-BENZYL-MORPHOLIN-2-YL)-ACETICACIDMETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1CN(CCO1)CC2=CC=CC=C2

Technology Process of Ethyl 2-(4-benzylmorpholin-2-yl)acetate

There total 5 articles about Ethyl 2-(4-benzylmorpholin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.04%

(E)-ethyl 4-bromobut-3-enoate + N-Benzylethanolamine (104-63-2) → ethyl 4-(phenylmethyl)-2-morpholineacetate (73933-19-4)

Guidance literature:

With triethylamine; In water; at 105 ℃; for 16h;

Reference yield: 43.0%

4-bromocrotonic ethyl ester (6065-32-3) + N-Benzylethanolamine (104-63-2) → ethyl 4-(phenylmethyl)-2-morpholineacetate (73933-19-4)

Guidance literature:

With triethylamine; In water; for 5h; Heating;

Reference yield:

4-bromo-trans-crotonic acid ethyl ester (37746-78-4) + N-Benzylethanolamine (104-63-2) → ethyl 4-(phenylmethyl)-2-morpholineacetate (73933-19-4)

Guidance literature:

4-bromo-trans-crotonic acid ethyl ester; N-Benzylethanolamine; With triethylamine; In water; for 5.15h; Reflux;

With sodium hydroxide; In water; at 25 ℃;

upstream raw materials:

4-bromocrotonic ethyl ester

N-Benzylethanolamine

4-bromo-trans-crotonic acid ethyl ester

Downstream raw materials:

2-(4-(tert-butoxycarbonyl)morpholin-2-yl)acetic acid

4-((2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)methyl)benzoic acid

2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetic acid

tert-butyl 2-(2-(tosyloxy)ethyl)morpholine-4-carboxylate