2-BENZYLAMINO-2-M-TOLYLACETIC ACID

Base Information

• Chemical Name: 2-BENZYLAMINO-2-M-TOLYLACETIC ACID
• CAS No.: 271583-30-3
• Molecular Formula: C16H17 N O2
• Molecular Weight: 255.31
• Mol file: 271583-30-3.mol

Synonyms:2-BENZYLAMINO-2-M-TOLYLACETIC ACID

Chemical Property of 2-BENZYLAMINO-2-M-TOLYLACETIC ACID

Chemical Property:

• Boiling Point: 404.4±33.0 °C(Predicted)
• PKA: 1.79±0.10(Predicted)
• PSA: 49.33000
• Density: 1.160±0.06 g/cm3(Predicted)
• LogP: 3.30140

Purity/Quality:

97% ^*data from raw suppliers

2-BENZYLAMINO-2-META-TOLYLACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYLAMINO-2-M-TOLYLACETIC ACID

There total 4 articles about 2-BENZYLAMINO-2-M-TOLYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-benzylamino-2-m-tolyl-acetamide (271583-50-7) → benzylamino-m-tolyl-acetic acid (271583-30-3)

Guidance literature:

With sodium hydroxide; water; In various solvent(s); for 3.5h; Heating;

DOI:10.1080/00397910008087127

Reference yield:

N-benzyl amino-(3-methylphenyl)acetonitrile (271583-72-3) → benzylamino-m-tolyl-acetic acid (271583-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / aq. H₂O₂; K₂CO₃ / dimethylsulfoxide / 16.5 h / 21 - 35 °C

2: 81 percent / NaOH; H₂O / various solvent(s) / 3.5 h / Heating

With sodium hydroxide; water; dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; 1: Hydrolysis / 2: Hydrolysis;

DOI:10.1080/00397910008087127

Reference yield:

m-tolyl aldehyde (620-23-5) → benzylamino-m-tolyl-acetic acid (271583-30-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂S₂O₅ / methanol; H₂O / 2 h / 35 °C

2: 94 percent / aq. H₂O₂; K₂CO₃ / dimethylsulfoxide / 16.5 h / 21 - 35 °C

3: 81 percent / NaOH; H₂O / various solvent(s) / 3.5 h / Heating

With sodium metabisulfite; sodium hydroxide; water; dihydrogen peroxide; potassium carbonate; In methanol; water; dimethyl sulfoxide; 1: Addition / 2: Hydrolysis / 3: Hydrolysis;

DOI:10.1080/00397910008087127

upstream raw materials:

2-benzylamino-2-m-tolyl-acetamide

N-benzyl amino-(3-methylphenyl)acetonitrile

m-tolyl aldehyde

benzylamine

Downstream raw materials:

2-amino-2-(3-methylphenyl)acetic acid

Refernces