methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate

Base Information

Chemical Name:methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate
CAS No.:1396312-93-8
Molecular Formula:C₄₂H₅₃N₇O₉
Molecular Weight:799.924
Hs Code.:

methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate

Synonyms:methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate

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Chemical Property of methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate

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Technology Process of methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate

There total 5 articles about methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1396312-83-6
(11-oxo-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-9-yl)methyl azide

: 1396312-85-8
(S)-2-{(S)-2-[(tert-butoxycarbonyl)amino]-3-(prop-2-ynyloxy)propanoylamino}-3-[methylbutanoylamino]-3-phenylpropanoic acid methyl ester

: 1396312-93-8
methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In water; dimethyl sulfoxide; at 80 ℃; for 16h;
DOI:10.1055/s-0031-1291145

Reference yield:

: 1107612-34-9
9-(chloromethyl)-2,3,6,7-tetrahydro-1H-pyr-ano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one

: 1396312-93-8
methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / acetone / 35 °C

2: copper(II) sulfate; sodium L-ascorbate / water; dimethyl sulfoxide / 16 h / 80 °C

With sodium azide; copper(II) sulfate; sodium L-ascorbate; In water; dimethyl sulfoxide; acetone; 2: Huisgen-Meldal-Shapeles reaction;
DOI:10.1055/s-0031-1291145

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 1396312-93-8
methyl (S)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-{1-[(10-oxo-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-8-yl)methyl]-1H-1,2,3-triazol-4-ylmethoxy}propanoylamino)-3-methylbutanoylamino]-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.25 h / 0 °C

1.2: 0 - 20 °C / Cooling with ice

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / ethly acetate / 0 - 20 °C

3.1: copper(II) sulfate; sodium L-ascorbate / water; dimethyl sulfoxide / 16 h / 80 °C

With sodium hydride; copper(II) sulfate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In ethly acetate; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 3.1: Huisgen-Meldal-Shapeles reaction;
DOI:10.1055/s-0031-1291145