4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid

Base Information

Chemical Name:4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid
CAS No.:869937-03-1
Molecular Formula:C₁₃H₉ClF₃N₃O₃
Molecular Weight:347.681
Hs Code.:

Synonyms:4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid

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Chemical Property of 4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid

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Technology Process of 4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid

There total 2 articles about 4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 878156-21-9
2-(4-benzyloxycarbonyl-2-methoxy-phenylamino)-4-chloro-5-trifluoromethyl-pyrimidine

: 869937-03-1
4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid

Guidance literature:: With hydrogen; palladium dihydroxide; at 20 ℃; for 16h; under 3000.3 Torr;

Reference yield: 2.0%

: 2486-69-3
3-methoxy-4-aminobenzoic acid

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 869937-03-1
4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid

Guidance literature:: 3-methoxy-4-aminobenzoic acid; 2,4-dichloro-5-trifluoromethylpyrimidine; In 1,4-dioxane; water; at 100 ℃; for 4h; pH=6.3; Aqueous phosphate buffer;

In hexane; Heating / reflux;

With hydrogenchloride; sodium hydrogencarbonate; more than 3 stages;