4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide

Base Information

Chemical Name:4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide
CAS No.:1283689-49-5
Molecular Formula:C₂₅H₃₃F₃N₆O₅S
Molecular Weight:586.635
Hs Code.:

4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide

Synonyms:4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide

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Chemical Property of 4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide

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Technology Process of 4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide

There total 3 articles about 4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1283691-19-9
4-[4-((1R,2R)-2-amino-cyclopentyloxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide

: 124-63-0
methanesulfonyl chloride

: 1283689-49-5
4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

Reference yield:

: 41838-46-4
4-Amino-1-methylpiperidine

: 1283689-49-5
4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / toluene / 2 h / 120 °C

1.2: 0 - 20 °C

2.1: sodium hydride / 1,4-dioxane / 30 h / 20 °C

2.2: 18 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With thionyl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 869937-03-1
4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzoic acid

: 1283689-49-5
4-{4-[(1R,2R)-2-(methanesulphonyl-methyl-amino)cyclopentyloxy]-5-trifluoromethyl-pyrimidin-2-ylamino}-3-methoxy-N-(1-methyl-piperidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / toluene / 2 h / 120 °C

1.2: 0 - 20 °C

2.1: sodium hydride / 1,4-dioxane / 30 h / 20 °C

2.2: 18 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With thionyl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; toluene;