9-Boc-6-oxa-9-azaspiro[4.5]decane

Base Information

Chemical Name:9-Boc-6-oxa-9-azaspiro[4.5]decane
CAS No.:271245-39-7
Molecular Formula:C₁₃H₂₃NO₃
Molecular Weight:241.331
Hs Code.:
DSSTox Substance ID:DTXSID60363860
Nikkaji Number:J1.282.632J
Wikidata:Q82147617
Mol file:271245-39-7.mol

Synonyms:271245-39-7;9-Boc-6-oxa-9-azaspiro[4.5]decane;Tert-butyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate;6-Oxa-9-azaspiro[4.5]decane-9-carboxylicacid, 1,1-dimethylethyl ester;SCHEMBL714947;DTXSID60363860;MFCD04038530;FT-0753460;1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate;6-Oxa-9-azaspiro[4.5]decane-9-carboxylic acid tert-butyl ester

Suppliers and Price of 9-Boc-6-oxa-9-azaspiro[4.5]decane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
9-BOC-6-OXA-9-AZASPIRO[4.5]DECANE 95.00%
1G
$ 1792.44

Total 3 raw suppliers

Chemical Property of 9-Boc-6-oxa-9-azaspiro[4.5]decane

Chemical Property:

Vapor Pressure:0.000136mmHg at 25°C
Refractive Index:1.501
Boiling Point:333.5°Cat760mmHg
Flash Point:155.5°C
PSA：38.77000
Density:1.08g/cm³
LogP:2.50440
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:241.16779360
Heavy Atom Count:17
Complexity:290

Purity/Quality:

97% ^*data from raw suppliers

9-BOC-6-OXA-9-AZASPIRO[4.5]DECANE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCOC2(C1)CCCC2

Technology Process of 9-Boc-6-oxa-9-azaspiro[4.5]decane

There total 3 articles about 9-Boc-6-oxa-9-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: [2-(1-iodomethyl-cyclopentyloxy)-ethyl]-carbamic acid tert-butyl ester

: 271245-39-7
1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4039(00)00016-2

Reference yield:

: 1528-30-9
methylenecyclopentane

: 271245-39-7
1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / N-iodosuccinimide / acetonitrile / 20 °C

2: 79 percent / NaH / dimethylformamide / 20 °C

With N-iodo-succinimide; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; 1: iodoetherification / 2: cyclocondensation;
DOI:10.1016/S0040-4039(00)00016-2

Reference yield:

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 271245-39-7
1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / N-iodosuccinimide / acetonitrile / 20 °C

2: 79 percent / NaH / dimethylformamide / 20 °C

With N-iodo-succinimide; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; 1: iodoetherification / 2: cyclocondensation;
DOI:10.1016/S0040-4039(00)00016-2