2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate

Base Information

Chemical Name:2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate
CAS No.:550355-94-7
Molecular Formula:C₂₁H₂₅Cl₃N₂O₈
Molecular Weight:539.797
Hs Code.:

Synonyms:2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate

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Chemical Property of 2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate

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Technology Process of 2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate

There total 5 articles about 2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 55110-70-8
2,2,2-trichloroethyl 2-bromoacetate

: 550355-92-5
allyl 5-hydroxy-2-{[(S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-4-methoxyphenylcarbamate

: 550355-94-7
2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm020526p

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 550355-94-7
2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: (COCl)2 / dimethylformamide

2: K₂CO₃

3: H₂ / Pd/C / methanol / 0.92 h / 2585.74 Torr

4: 85 percent / pyridine / tetrahydrofuran / 0.17 h / -78 °C

5: 80 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

With pyridine; oxalyl dichloride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020526p

Reference yield:

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 550355-94-7
2,2,2-trichloroethyl (5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃

2: H₂ / Pd/C / methanol / 0.92 h / 2585.74 Torr

3: 85 percent / pyridine / tetrahydrofuran / 0.17 h / -78 °C

4: 80 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

With pyridine; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020526p