4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene

Base Information

• Chemical Name: 4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene
• CAS No.: 26082-28-0
• Molecular Formula: C₂₅H₂₆N₂O₄
• Molecular Weight: 418.492
• Mol file: 26082-28-0.mol

Synonyms:4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene

Chemical Property of 4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene

There total 1 articles about 4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

thebaine (115-37-7) + Nitrosobenzene (586-96-9) → 4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene (26082-28-0)

Guidance literature:

In dichloromethane;

DOI:10.1021/jm00180a028

Reference yield: 91.0%

4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene (26082-28-0) → C24H24N2O4*ClH

Guidance literature:

With hydrogenchloride; for 3h;

DOI:10.1021/jm00180a028

Reference yield:

4,5α-epoxy-3,6-dimethoxy-17-methyl-18-phenyl-6β,14-oxaazaethano-morphin-7-ene (26082-28-0) → C24H26N2O3

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / HCl / 3 h

2: 57 percent / H₂ / 10percent Pd/C / methanol / 2.5 h / 2896.03 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00180a028

upstream raw materials:

thebaine

Nitrosobenzene

Downstream raw materials:

4,5α-epoxy-14-(N-hydroxy-anilino)-3-methoxy-17-methyl-morphin-7-en-6-one

14-anilino-4,5α-epoxy-3-methoxy-17-methyl-morphinan-6-one

14-(N-acetoxy-anilino)-4,5α-epoxy-3-methoxy-17-methyl-morphin-7-en-6-one

4-hydroxy-3-methoxy-17-methyl-18-phenyl-5β,14-oxaazaethano-morphin-7-en-6-one