(2S,R_S)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol

Base Information

• Chemical Name: (2S,R_S)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol
• CAS No.: 1402352-67-3
• Molecular Formula: C₁₆H₁₇F₂NO₃S
• Molecular Weight: 341.379

Synonyms:(2S,R_S)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol

Chemical Property of (2S,R_S)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol

Chemical Property:

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Technology Process of (2S,R_S)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol

There total 3 articles about (2S,R_S)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H31F2NO3SSi → (2S,RS)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol (1402352-67-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at -98 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja308419a

Reference yield:

2-((R)-N-(tert-butyldimethylsilyl)phenylsulfonimidoyl)-2-fluoro-1-phenylethanone → (2S,RS)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol (1402352-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -98 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / -98 - 20 °C / Inert atmosphere

With hydrogenchloride; potassium hexamethylsilazane; lithium hexamethyldisilazane; In tetrahydrofuran; water;

DOI:10.1021/ja308419a

Reference yield:

(R)-N-tert-butyldimethylsilyl-S-monofluoromethyl-S-phenylsulfoximine (825638-25-3) → (2S,RS)-1,1-difluoro-2-(2-methoxyphenyl)-1-(phenylsulfonimidoyl)propan-2-ol (1402352-67-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -98 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / -98 - 20 °C / Inert atmosphere

With hydrogenchloride; potassium hexamethylsilazane; lithium hexamethyldisilazane; In tetrahydrofuran; water;

DOI:10.1021/ja308419a

upstream raw materials:

(R)-N-tert-butyldimethylsilyl-S-monofluoromethyl-S-phenylsulfoximine

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