1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole

Base Information

• Chemical Name: 1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole
• CAS No.: 777943-24-5
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348
• Mol file: 777943-24-5.mol

Synonyms:1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole

Chemical Property of 1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole

There total 3 articles about 1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 2-(1H-indole-3-carbonyl)benzoate (6243-59-0) + chloromethyl methyl ether (107-30-2) → 1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole (777943-24-5)

Guidance literature:

methyl 2-(1H-indole-3-carbonyl)benzoate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

chloromethyl methyl ether; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm049625o

Reference yield:

indole (120-72-9) → 1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole (777943-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ZnCl₂; MeMgCl / CH₂Cl₂ / 1 h / 20 °C

1.2: 76 percent / CH₂Cl₂ / 20 °C

2.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

2.2: 93 percent / tetrahydrofuran / 16 h / 20 °C

With methylmagnesium chloride; sodium hydride; zinc(II) chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm049625o

Reference yield:

phthalic monoacid monomethyl ester chloride (4397-55-1) → 1-methoxymethyl-3-(1-methoxycarbonylbenzene-2-yl)carbonylindole (777943-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ZnCl₂; MeMgCl / CH₂Cl₂ / 1 h / 20 °C

1.2: 76 percent / CH₂Cl₂ / 20 °C

2.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

2.2: 93 percent / tetrahydrofuran / 16 h / 20 °C

With methylmagnesium chloride; sodium hydride; zinc(II) chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm049625o

upstream raw materials:

methyl 2-(1H-indole-3-carbonyl)benzoate

chloromethyl methyl ether

indole

phthalic monoacid monomethyl ester chloride