3''-METHOXYOROBOL

Base Information

• Chemical Name: 3''-METHOXYOROBOL
• CAS No.: 36190-95-1
• Molecular Formula: C16H12 O6
• Molecular Weight: 300.268
• Hs Code.: 2914509090
• Mol file: 36190-95-1.mol

Synonyms:5,7,4'-trihydroxy-3',6-dimethoxyflavone;3'-methoxy-4',5,7-trihydroxyisoflavone;5,7,4'-trihydroxy-6,3'-dimethoxyflavone;JACEOSIDINE;3'-methylorobol;3'-O-methylorobol;5,7,4'-trihydroxy-3'-methoxyisoflavone;4',5,7-Trihydroxy-3',6-dimethoxyflavone;orobol 3'-methyl ether;Jaceosidin;

Chemical Property of 3''-METHOXYOROBOL

Chemical Property:

• PSA: 100.13000
• LogP: 2.58540

Purity/Quality:

Analysis control,HPLC≥98% ^*data from raw suppliers

3''-Methoxy-4'',5,7-trihydroxyisoflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3''-Methoxy-4'',5,7-trihydroxyisoflavone is a derivative of Genistein (G350000); a compound that exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2.

Technology Process of 3''-METHOXYOROBOL

There total 3 articles about 3''-METHOXYOROBOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

orobol (480-23-9) → 3',5,7-trihydroxy-4'-methoxyisoflavone (2284-31-3) + 3'-O-methylorobol (36190-95-1)

Guidance literature:

With (R,S)-S-adenosyl-L-methionine; In dimethyl sulfoxide; at 40 ℃; for 24h; Enzymatic reaction;

DOI:10.3390/molecules22010087

Reference yield:

homoeriodictyol (446-71-9,69097-98-9,107657-60-3) → 3'-O-methylorobol (36190-95-1)

Guidance literature:

With NADP; D-Galactose; In dimethyl sulfoxide; at 30 ℃; for 72h; Microbiological reaction;

DOI:10.1016/j.chembiol.2010.03.010

Reference yield:

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on (446-72-0) → 3-(3,4-dimethoxyphenyl)-5,7-dihydroxy-4H-chromen-4-one (53084-11-0) + 3'-O-methylorobol (36190-95-1) + 5,7,3',4'-tetrahydroxy-8-methylisoflavone + 5,7,3',4'-tetrahydroxy-8-methylisoflavanone

Guidance literature:

for 144h;

DOI:10.1021/np9901783

upstream raw materials:

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

homoeriodictyol

orobol