Technology Process of ethyl 3-[5-(2,6-dimethyl-4-phosphonomethoxybenzyl)-2-hydroxyphenyl]propanoate
There total 6 articles about ethyl 3-[5-(2,6-dimethyl-4-phosphonomethoxybenzyl)-2-hydroxyphenyl]propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 1.5 h / Industry scale
1.2: 4 - 20 °C / Industry scale
1.3: 6.5 h / pH 5 / Industry scale
2.1: caesium carbonate / dimethyl sulfoxide / 8 h / 50 - 60 °C
3.1: methanesulfonic acid / dichloromethane / -40 - 0 °C
4.1: trimethylsilyl bromide / dichloromethane / 16 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; methanesulfonic acid; trimethylsilyl bromide; caesium carbonate; sodium hydroxide;
In
1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: caesium carbonate / dimethyl sulfoxide / 8 h / 50 - 60 °C
2: methanesulfonic acid / dichloromethane / -40 - 0 °C
3: trimethylsilyl bromide / dichloromethane / 16 h / 20 °C
4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; methanesulfonic acid; trimethylsilyl bromide; caesium carbonate;
In
1,4-dioxane; dichloromethane; dimethyl sulfoxide;
