dimethyl 6-cyclopropyl-4-phenyl-1-tosyl-1,6-dihydropyridine-2,3-dicarboxylate

Base Information

• Chemical Name: dimethyl 6-cyclopropyl-4-phenyl-1-tosyl-1,6-dihydropyridine-2,3-dicarboxylate
• CAS No.: 1428550-12-2
• Molecular Formula: C₂₅H₂₅NO₆S
• Molecular Weight: 467.543
• Mol file: 1428550-12-2.mol

Synonyms:dimethyl 6-cyclopropyl-4-phenyl-1-tosyl-1,6-dihydropyridine-2,3-dicarboxylate

Chemical Property of dimethyl 6-cyclopropyl-4-phenyl-1-tosyl-1,6-dihydropyridine-2,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 6-cyclopropyl-4-phenyl-1-tosyl-1,6-dihydropyridine-2,3-dicarboxylate

There total 2 articles about dimethyl 6-cyclopropyl-4-phenyl-1-tosyl-1,6-dihydropyridine-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl 2-(N-(1-cyclopropyl-3-phenylprop-2-yn-1-yl)-4-methylphenylsulfonamido)maleate → dimethyl 6-cyclopropyl-4-phenyl-1-tosyl-1,6-dihydropyridine-2,3-dicarboxylate (1428550-12-2)

Guidance literature:

In ethanol; at 70 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2013.10.038

Reference yield:

C19H19NO2S (1428549-95-4) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 6-cyclopropyl-4-phenyl-1-tosyl-1,6-dihydropyridine-2,3-dicarboxylate (1428550-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / dichloromethane / Inert atmosphere; Schlenk technique

2: methanol / 48 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube

With caesium carbonate; In methanol; dichloromethane;

DOI:10.1021/jo400387b

upstream raw materials:

C₁₉H₁₉NO₂S

dimethyl acetylenedicarboxylate