Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Base Information

• Chemical Name: Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide
• CAS No.: 103407-24-5
• Molecular Formula: C₂₁H₁₆FN₃O₂S
• Molecular Weight: 393.441

Synonyms:Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Chemical Property of Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Chemical Property:

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Technology Process of Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

There total 2 articles about Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-thiophene carboxylic acid chloride (41507-35-1) + 1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-(aminomethyl)-2H-1,4-benzodiazepin-2-one (103343-37-9) → Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide (103407-24-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 23 ℃;

DOI:10.1021/jm00163a069

Reference yield:

N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide (103343-35-7) → Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide (103407-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / hydrazine / methanol / 14 h / 23 °C

2: 67 percent / triethylamine / tetrahydrofuran / 0 - 23 °C

With triethylamine; hydrazine; In tetrahydrofuran; methanol;

DOI:10.1021/jm00163a069

upstream raw materials:

3-thiophene carboxylic acid chloride

1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-(aminomethyl)-2H-1,4-benzodiazepin-2-one

N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

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