N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

Base Information

Chemical Name:N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide
CAS No.:103343-35-7
Molecular Formula:C₃₂H₂₀FN₃O₆
Molecular Weight:561.526
Hs Code.:

Synonyms:N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

Chemical Property:

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Technology Process of N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

There total 1 articles about N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1581-13-1
2-amino-2'-fluorobenzophenone

: 103343-36-8
2,3-Diphthalylaminopropionyl chloride

: 103343-35-7
N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

Guidance literature:: In tetrahydrofuran; for 2.5h; Ambient temperature;

Reference yield: 90.0%

: 103343-35-7
N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

: 103343-37-9
1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-(aminomethyl)-2H-1,4-benzodiazepin-2-one

Guidance literature:: With hydrazine; In methanol; at 23 ℃; for 14h;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-35-7
N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

: 123903-97-9
1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / hydrazine / methanol / 14 h / 23 °C

2: 97 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 23 °C / overnight

3: 95 percent / Lawesson's reagent / toluene / 1.5 h / Heating

4: 50 percent / W-2 Raney nickel / ethanol / 50 h

5: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

With Lawessons reagent; dmap; hydrogen bromide; hydrazine; W-2 Raney nickel; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jm00163a069