acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester

Base Information

Chemical Name:acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester
CAS No.:345922-12-5
Molecular Formula:C₂₈H₂₈NO₃P
Molecular Weight:457.509
Hs Code.:

acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ<sup>5</sup>-phosphanylidene)-butyl ester

Synonyms:acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester

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Chemical Property of acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester

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Technology Process of acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester

There total 8 articles about acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-36-5
acetyl chloride

: 345922-13-6
5-hydroxy-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

: 345922-12-5
acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester

Guidance literature:: In dichloromethane; at 40 ℃; for 4h;
DOI:10.1021/jo0015974

Reference yield:

: 10191-24-9,66997-60-2,77877-35-1,88930-06-7
3-hydroxyhexanoic acid

: 345922-12-5
acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: EDCI

2: 100 percent / CH₂Cl₂ / 4 h / 40 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jo0015974

Reference yield:

: 2305-25-1
3-hydroxy-hexanoic acid ethyl ester

: 345922-12-5
acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: 100 percent / aq. NaOH / methanol / 19 h / 100 °C

3: 57 percent / EDCI; DMAP / CH₂Cl₂ / 5 h / 20 °C

4: 78 percent / HCl / ethanol / 20 °C

5: 100 percent / CH₂Cl₂ / 4 h / 40 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0015974