5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

Base Information

• Chemical Name: 5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride
• CAS No.: 1411702-70-9
• Molecular Formula: C₂₉H₂₉NO₂P*Cl
• Molecular Weight: 489.982
• Mol file: 1411702-70-9.mol

Synonyms:5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

Chemical Property of 5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride

There total 3 articles about 5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

α4,3-O-isopropylidene-α5-pyridoxyl chloride (14142-90-6) + triphenylphosphine (603-35-0) → 5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride (1411702-70-9)

Guidance literature:

In acetonitrile; for 7h; Reflux;

DOI:10.1016/j.bmc.2013.04.051

Reference yield:

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol (1136-52-3) → 5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride (1411702-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 2 h / 25 °C

2: acetonitrile / 7 h / Reflux

With thionyl chloride; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2013.04.051

Reference yield:

pyridoxal hydrochloride (58-56-0) → 5-[(triphenylphosphonio)methyl]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine chloride (1411702-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 3 h / 20 °C

2: thionyl chloride / dichloromethane / 2 h / 25 °C

3: acetonitrile / 7 h / Reflux

With hydrogenchloride; thionyl chloride; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2013.04.051

upstream raw materials:

α⁴,3-O-isopropylidene-α⁵-pyridoxyl chloride

triphenylphosphine

pyridoxal hydrochloride

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

Downstream raw materials:

5-[(triphenylphosphonio)methyl]-3-hydroxy-4-(hydroxymethyl)-2-methylpyridin-1-ium dichloride