Ethyl 2-hydroxy-4-methoxybenzoate

Base Information

• Chemical Name: Ethyl 2-hydroxy-4-methoxybenzoate
• CAS No.: 35031-00-6
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.203
• DSSTox Substance ID: DTXSID401299096
• Nikkaji Number: J2.889.948C
• Mol file: 35031-00-6.mol

Synonyms:ethyl 2-hydroxy-4-methoxybenzoate;Ethyl 4-methoxysalicylate;35031-00-6;Benzoic acid, 2-hydroxy-4-methoxy-, ethyl ester;SCHEMBL17779153;DTXSID401299096;AKOS008948907;FS-7830

Chemical Property of Ethyl 2-hydroxy-4-methoxybenzoate

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 196.07355886
• Heavy Atom Count: 14
• Complexity: 193

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C(C=C(C=C1)OC)O

Technology Process of Ethyl 2-hydroxy-4-methoxybenzoate

There total 8 articles about Ethyl 2-hydroxy-4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 4-methoxybenzoate (94-30-4) → ethyl 2-hydroxy-4-methoxybenzoate (35031-00-6)

Guidance literature:

With dipotassium peroxodisulfate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; trifluoroacetic acid; trifluoroacetic anhydride; at 78 ℃; for 10h;

DOI:10.1021/ol301104n

Reference yield:

ethanol (64-17-5) + 4-methoxysalicylic acid (2237-36-7) → ethyl 2-hydroxy-4-methoxybenzoate (35031-00-6)

Guidance literature:

With sulfuric acid;

Reference yield:

4-hydroxysalicylic acid (89-86-1) → ethyl 2-hydroxy-4-methoxybenzoate (35031-00-6)

Guidance literature:

Multi-step reaction with 2 steps

2: H₂SO₄

With sulfuric acid;

upstream raw materials:

ethanol

4-methoxysalicylic acid

ethyl 3-methoxyphenyl carbonate

4-hydroxysalicylic acid

Downstream raw materials:

5-Methoxy-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol

3-benzothiazol-2-yl-7-hydroxy-chromen-4-one

2-(5-(benzylthio)-1,3,4-oxadiazol-2-yl)-5-methoxyphenol

2-(5-mercapto-1,3,4-oxadiazol-2-yl)-5-methoxyphenol