(4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate

Base Information

Chemical Name:(4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate
CAS No.:1253191-33-1
Molecular Formula:C₂₉H₃₆Cl₂N₂O₇
Molecular Weight:595.52
Hs Code.:

Synonyms:(4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate

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Chemical Property of (4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate

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Technology Process of (4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate

There total 5 articles about (4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1253191-50-2
(4S)-1-tert-butyl 3-ethyl-4-amino-piperidine-1,3-dicarboxylate

: 1253191-37-5
4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzoic acid

: 1253191-33-1
(4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃; Inert atmosphere;

Reference yield:

: 2432-12-4
2,6-dichloro-4-methylophenol

: 1253191-33-1
(4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine / 6 h / 140 °C

2: triethylamine / dichloromethane / 6 h / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 - 100 °C

4: water; lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 25 °C / Inert atmosphere

With piperidine; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1228766-25-3
2-(2,6-dichloro-4-methylphenoxy)ethyl methanesulfonate

: 1253191-33-1
(4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 - 100 °C

2: water; lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 25 °C / Inert atmosphere

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;