2432-12-4

Basic information

• Product Name: 2,6-Dichloro-4-methylphenol
• Synonyms: 2,6-DICHLORO-P-CRESOL;2,6-DICHLORO-4-METHYLPHENOL;2,6-dichloro-4-methyl-pheno;2,6-Dichlorocresol;2,6-Dichloro-p-methylphenol;2,6-DICHLORO-P-CRESOL 96+%;2,6-Dichloro-p-cresol, 3,5-Dichloro-4-hydroxytoluene;2,6-Dichloro-p-cresol
• CAS NO: 2432-12-4
• Molecular Formula: C₇H₆Cl₂O
• Molecular Weight: 177.03
• EINECS: 219-402-4
• Mol File: 2432-12-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 39°C
• Boiling Point: 251.88°C (rough estimate)
• Flash Point: 34 °C
• Appearance: /
• Density: 1.2970 (rough estimate)
• Vapor Pressure: 0.0595mmHg at 25°C
• Refractive Index: 1.5625 (estimate)
• Storage Temp.: 2-8°C
• PKA: 7.34±0.23(Predicted)
• Water Solubility: 283.3mg/L(25 oC)
• CAS DataBase Reference: 2,6-Dichloro-4-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-4-methylphenol(2432-12-4)
• EPA Substance Registry System: 2,6-Dichloro-4-methylphenol(2432-12-4)

Safety Data

• Statements: 20/21/22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 2432-12-4(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-4-methylphenol, also known as DCP, is a chemical compound with the molecular formula C7H6Cl2O. It is a white or off-white crystalline solid that is soluble in organic solvents but only slightly soluble in water. DCP is widely used as a disinfectant and antiseptic in various pharmaceutical and personal care products. It is also used in the preservation of wood and as a biocide in water treatment. DCP is known for its antimicrobial properties, making it an effective agent for preventing the growth of bacteria, fungi, and algae. However, it is also considered toxic to aquatic organisms and should be handled with caution.

InChI:InChI=1/C7H6Cl2O/c1-4-2-5(8)7(10)6(9)3-4/h2-3,10H,1H3

Upstream product

• 6640-27-3 2-chloro-p-cresol 
• 7791-25-5 sulfuryl dichloride 
• 106-44-5 p-cresol 
• 7782-50-5 chlorine 
• 56-23-5 tetrachloromethane 
• 7732-18-5 water 
• 7647-01-0 hydrogenchloride 
• 67828-41-5 2,6-dichloro-4-methyl-phenetole 
• 98712-54-0 4-hydroxy-toluene-3,5-disulfonic acid 
• 859820-20-5 2-chloro-6-(2,6-dichloro-4-methyl-phenoxy)-6-methoxy-4-methyl-cyclohexa-2,4-dienone 
• 10035-10-6 hydrogen bromide 
• 15719-64-9 methylammonium carbonate 
• 104678-53-7 2,6-dichloro-4-methyl-4-nitrocyclohexa-2,5-dienone 
• 64-19-7 acetic acid 

Downstream Products

• 69557-53-5 1-(2,6-dichloro-4-methyl-phenoxy)-propan-2-ol 
• 67341-33-7 2,6-dichloro-4-methylanisole 
• 32862-39-8 1,3-Dichloro-2-(3-methoxy-4-nitro-phenoxy)-5-methyl-benzene 
• 61306-38-5 2,6-dichloro-4-methoxy-4-methylcyclohexa-2,5-dienone 
• 7731-29-5 trans-4-methylcyclohexan-1-ol 
• 7731-28-4 cis-4-methylcyclohexanol 
• 19384-38-4 O-(2,6-Dichlor-4-tolyl)-S-(N,N-dimethyl-thiocarbamoyl)-dithiocarbonat 
• 19378-20-2 O-(2,6-Dichlor-4-tolyl)-S-(N,N-diethyl-thiocarbamoyl)-dithiocarbonat 
• 100-02-7 4-nitro-phenol 
• 2314-36-5 3,5-dichloro-4-hydroxybenzaldehyde 
• 79817-03-1 3,5-dichloro-4-hydroxybenzyl methyl ether 
• 37908-97-7 3,5-dichloro-4-methoxybenzoic acid 
• 3337-59-5 methyl 3,5-dichloro-4-hydroxybenzoate 
• 3336-41-2 3,5-dichloro-4-hydroxybenzoic acid 

Relevant articles and documents

Regioselective C-H chlorination: Towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds

We have developed a protocol for the auxillary directed C-H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone. The 2-pyridine group allows for a highly efficient palladium-catalyzed chlorination and sequential ortho C-H functionalization reaction of phenol derivatives to produce a variety of symmetrical and unsymmetrical 2,4,6-trisubstituted phenols.

A practical synthesis of renin inhibitor MK-1597 (ACT-178882) via catalytic enantioselective hydrogenation and epimerization of piperidine intermediate

A practical enantioselective synthesis of renin inhibitor MK-1597 (ACT-178882), a potential new treatment for hypertension, is described. The synthetic route provided MK-1597 in nine steps and 29% overall yield from commercially available p-cresol (7). The key features of this sequence include a catalytic asymmetric hydrogenation of a tetrasubstituted ene-ester, a highly efficient epimerization/saponification sequence of 4 which sets both stereocenters of the molecule, and a short synthesis of amine fragment 2.

A PROCESS FOR PREPARING DIAZABICYCLO[3.3.1] NONANE COMPOUNDS

The invention is a process for preparing a diazabicyclo compound of formula (I) process for preparing a diazabicyclo compound of formula (I):where X is selected from the group consisting of hydrogen, C1-C6 alkoxycarbonyl, and carbobenzyloxy; R6 is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, and benzyl; and R9, R 10, and R11 are independently selected from the group consisting of hydrogen, halogen, and C1-C6 alkyl. wherein the process involves cyclizing I-I, formula (II).