N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide

Base Information

Chemical Name:N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide
CAS No.:1421054-58-1
Molecular Formula:C₂₁H₃₃NO₂Si
Molecular Weight:359.584
Hs Code.:

Synonyms:N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide

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Technology Process of N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide

There total 6 articles about N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1421054-57-0
N-((1R,3S)-1-hydroxy-1-phenylhex-5-en-3-yl)acrylamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1421054-58-1
N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/ol303364j

Reference yield:

: 1421054-55-8
((2S,4R,6R)-4-acrylamido-6-phenyltetrahydro-2H-pyran-2-yl)methyl-4-methylbenzenesulfonate

: 1421054-58-1
N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide / acetone / 24 h / Reflux

2: zinc / ethanol / 8 h / Reflux

3: dmap; 1H-imidazole / dichloromethane / 6 h / 20 °C

With 1H-imidazole; dmap; sodium iodide; zinc; In ethanol; dichloromethane; acetone;
DOI:10.1021/ol303364j

Reference yield:

: 1421054-56-9
N-((2S,4R,6R)-2-(iodomethyl)-6-phenyltetrahydro-2H-pyran-4-yl)acrylamide

: 1421054-58-1
N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: zinc / ethanol / 8 h / Reflux

2: dmap; 1H-imidazole / dichloromethane / 6 h / 20 °C

With 1H-imidazole; dmap; zinc; In ethanol; dichloromethane;
DOI:10.1021/ol303364j