ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate

Base Information

• Chemical Name: ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate
• CAS No.: 1233319-98-6
• Molecular Formula: C₃₇H₅₂O₁₃
• Molecular Weight: 704.812
• Mol file: 1233319-98-6.mol

Synonyms:ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate

Chemical Property of ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate

There total 2 articles about ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-oxo-6-hydroxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (867187-58-4) + 28-bromo-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane (125562-30-3) → ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate (1233319-98-6)

Guidance literature:

1-oxo-6-hydroxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

28-bromo-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1002/pola.24016

Reference yield:

2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol (6048-68-6) → ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate (1233319-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus tribromide / diethyl ether / 0 °C

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 72 h / 20 °C

With phosphorus tribromide; potassium carbonate; potassium iodide; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1002/pola.24016

Reference yield: 74.0%

ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate (1233319-98-6) + trimethylaluminum (75-24-1) → ethyl 1-hydroxy-1-methyl-6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-3-phenyl-1H-indene-2-carboxylate (1233320-01-8)

Guidance literature:

In tetrahydrofuran; dichloromethane; for 0.5h; Inert atmosphere;

DOI:10.1002/pola.24016

upstream raw materials:

1-oxo-6-hydroxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

28-bromo-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane

2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

Downstream raw materials:

ethyl 1-methylene-6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-3-phenyl-1H-indene-2-carboxylate

ethyl 1-hydroxy-1-methyl-6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-3-phenyl-1H-indene-2-carboxylate