4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine

Base Information

Chemical Name:4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine
CAS No.:137845-12-6
Molecular Formula:C₂₆H₂₅NO₂S₂
Molecular Weight:447.622
Hs Code.:

Synonyms:4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine

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Chemical Property of 4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine

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Technology Process of 4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine

There total 3 articles about 4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 51985-30-9,137845-37-5,144381-72-6
4-Methyl-N-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-benzenesulfonamide

: 137845-08-0
2,2-Dimethyl-propionic acid (Z)-3-phenylsulfanyl-2-trimethylsilanylmethyl-allyl ester

: 137845-12-6
4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine

Guidance literature:: With palladium diacetate; triisopropyl phosphite; In 1,4-dioxane; at 65 - 95 ℃;
DOI:10.1021/ja00023a094

Reference yield:

: 89005-19-6
3-(phenylsulfanyl)propargyl alcohol

: 137845-12-6
4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / s-C₄H₉MgCl, CuCl / diethyl ether

2: 92 percent / C₅H₅N, DMAP / CH₂Cl₂ / 0 °C

3: 80 percent / Pd(OAc)2, (i-C₃H₇O)3P / dioxane / 65 - 95 °C

With pyridine; dmap; palladium diacetate; triisopropyl phosphite; s-butylmagnesium chloride; copper(l) chloride; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/ja00023a094

Reference yield:

: (Z)-3-(phenylthio)-2-((trimethylsilyl)methyl)prop-2-en-1-ol

: 137845-12-6
4-Methylene-3-phenylsulfanyl-2-((E)-styryl)-1-(toluene-4-sulfonyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / C₅H₅N, DMAP / CH₂Cl₂ / 0 °C

2: 80 percent / Pd(OAc)2, (i-C₃H₇O)3P / dioxane / 65 - 95 °C

With pyridine; dmap; palladium diacetate; triisopropyl phosphite; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ja00023a094