3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime

Base Information

• Chemical Name: 3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime
• CAS No.: 100157-36-6
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Mol file: 100157-36-6.mol

Synonyms:3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime

Chemical Property of 3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime

There total 9 articles about 3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(3,4-Dimethoxyphenyl)propanal (61871-67-8) → 3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime (100157-36-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; Heating;

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime (100157-36-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / LiOCH₃ / methanol; dimethylformamide / 24 h / 80 °C

2: 95 percent / H₂ / Pd/C / dioxane / 3102.9 Torr

3: 65 percent / aq. HCl 6N / dioxane / 4 h / Heating

4: 85 percent / NH₂OH*HCl, CH₃COONa / H₂O; ethanol / Heating

With hydrogenchloride; hydroxylamine hydrochloride; lithium methanolate; hydrogen; sodium acetate; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

3-(3,4-dimethoxyphenyl)-1,1-ethylendioxy-2-propene (100157-46-8) → 3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime (100157-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂ / Pd/C / dioxane / 3102.9 Torr

2: 65 percent / aq. HCl 6N / dioxane / 4 h / Heating

3: 85 percent / NH₂OH*HCl, CH₃COONa / H₂O; ethanol / Heating

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; palladium on activated charcoal; In 1,4-dioxane; ethanol; water;

upstream raw materials:

3-(3,4-Dimethoxyphenyl)propanal

3,4-dimethoxy-benzaldehyde

3-(3,4-dimethoxyphenyl)-1,1-ethylendioxypropane

3-(3,4-dimethoxyphenyl)-1,1-ethylendioxy-2-propene

Refernces

• 1、 Bellucci,Teodori,Gualtieri. "Search for new Ca++ antagonists. Lipophilic oximes and phosphonates". . p. 730 - 744. Retrieved 2007/10/02.