(S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester

Base Information

Chemical Name:(S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester
CAS No.:914604-97-0
Molecular Formula:C₃₀H₃₇N₃O₄
Molecular Weight:503.641
Hs Code.:

Synonyms:(S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester

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Chemical Property of (S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester

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Technology Process of (S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester

There total 7 articles about (S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 914604-96-9
1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

: 914604-97-0
(S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 2h;

Reference yield:

: 128019-27-2
2-benzyloxycarbonyl-1,2,3,4-tetrahydropyrido[3,4-b]indole-1-carboxylic acid

: 914604-97-0
(S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 2 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 6 h / -78 °C

3: sodium acetate; sodium cyanoborohydride / isopropyl alcohol / 1 h / 20 °C / molecular sieves

4: potassium carbonate / tetrahydrofuran / 96 h / 50 °C

5: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

With hydrogen; sodium acetate; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 914604-94-7
1-formyl-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

: 914604-97-0
(S)-[tert-butoxycarbonyl-(2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; sodium cyanoborohydride / isopropyl alcohol / 1 h / 20 °C / molecular sieves

2: potassium carbonate / tetrahydrofuran / 96 h / 50 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

With hydrogen; sodium acetate; sodium cyanoborohydride; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; isopropyl alcohol;