1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

Base Information

Chemical Name:1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester
CAS No.:914604-96-9
Molecular Formula:C₃₈H₄₃N₃O₆
Molecular Weight:637.776
Hs Code.:

1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

Synonyms:1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

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Chemical Property of 1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

There total 6 articles about 1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 914604-95-8
1-{[((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 914604-96-9
1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 50 ℃; for 96h;

Reference yield:

: 128019-27-2
2-benzyloxycarbonyl-1,2,3,4-tetrahydropyrido[3,4-b]indole-1-carboxylic acid

: 914604-96-9
1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 2 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 6 h / -78 °C

3: sodium acetate; sodium cyanoborohydride / isopropyl alcohol / 1 h / 20 °C / molecular sieves

4: potassium carbonate / tetrahydrofuran / 96 h / 50 °C

With sodium acetate; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 914604-93-6
1-(methoxy-methyl-carbamoyl)-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

: 914604-96-9
1-{[tert-butoxycarbonyl-((S)-cyclopentyloxycarbonyl-phenyl-methyl)-amino]-methyl}-1,3,4,9-tetrahydro-beta-carboline-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 6 h / -78 °C

2: sodium acetate; sodium cyanoborohydride / isopropyl alcohol / 1 h / 20 °C / molecular sieves

3: potassium carbonate / tetrahydrofuran / 96 h / 50 °C

With sodium acetate; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; In tetrahydrofuran; isopropyl alcohol; toluene;