3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide

Base Information

Chemical Name:3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide
CAS No.:1312593-85-3
Molecular Formula:C₂₇H₂₄ClN₅O₂S₂
Molecular Weight:550.105
Hs Code.:

Synonyms:3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide

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Chemical Property of 3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide

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Technology Process of 3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide

There total 8 articles about 3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 857283-63-7
1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine

: 1312595-04-2
1,1-dimethylethyl 4-(3-bromo-4-{[(3-chlorophenyl)sulfonyl]amino}-6-methylthieno[2,3-b]pyridin-2-yl)-1H-pyrazole-1-carboxylate

: 1312593-85-3
3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide

Guidance literature:: With water; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Product distribution / selectivity; microwave irradiation;

Reference yield:

: 4651-82-5
2-amino-3-cyanothiophene

: 1312593-85-3
3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tin(IV) chloride / toluene / 4.5 h / 20 °C / Reflux

1.2: 20 °C

2.1: bromine; acetic acid / 20 °C

3.1: sodium t-butanolate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane; water / 2 h / 100 °C

5.1: bromine / chloroform / 4 h / 60 °C

6.1: sodium hydroxide; water / dimethyl sulfoxide / 1.5 h / 150 °C

6.2: 20 °C / pH ~ 4 - 5

6.3: 1 h / 200 °C

7.1: dmap; triethylamine / acetonitrile / 1.5 h / 20 °C

8.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,4-dioxane / 0.5 h / 120 °C / microwave irradiation

With dmap; water; bromine; tin(IV) chloride; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; sodium t-butanolate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1312594-89-0
ethyl 4-amino-6-methylthieno[2,3-b]pyridine-5-carboxylate

: 1312593-85-3
3-chloro-N-{6-methyl-2-(1H-pyrazol-4-yl)-3-[3-(1-pyrrolidinyl)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine; acetic acid / 20 °C

2.1: sodium t-butanolate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane; water / 2 h / 100 °C

4.1: bromine / chloroform / 4 h / 60 °C

5.1: sodium hydroxide; water / dimethyl sulfoxide / 1.5 h / 150 °C

5.2: 20 °C / pH ~ 4 - 5

5.3: 1 h / 200 °C

6.1: dmap; triethylamine / acetonitrile / 1.5 h / 20 °C

7.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,4-dioxane / 0.5 h / 120 °C / microwave irradiation

With dmap; water; bromine; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; sodium t-butanolate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;